Chicago, 1968. As a city and the nation are poised on the brink of violent political upheaval, suburban housewife Joy leads an ordinary life with her husband and daughter. When Joy’s pregnancy leads to a life-threatening condition, she must navigate a medical establishment unwilling to help. Her journey to find a solution to an impossible situation leads her to the “Janes,” a clandestine organization of women who provide Joy with a safer alternative — and in the process, change her life.